Sharon A. Stranford Associate Professor stranford@mtholyoke.edu 413-538-2573 Office: Carr 120D CV EDUCATION B.A. Biology, Arcadia University, 1985 Ph.D. Microbiology and Immunology, Drexel University, 1992 POSTDOCTORAL TRAINING Oxford University, Nuffield Dept. of Surgery, England, 1992-1995 University of California, San Francisco, Dept. of Medicine, 1995-1999 RESEARCH INTERESTS My research interests involve the study of immunologic correlates to protection from retroviral infection and disease progression. I have studied several potential correlates to protection from HIV, including noncytotoxic CD8+ T cell responses, in uninfected high-risk populations. Currently, we use an animal model system in my laboratory (Murine Leukemia Virus-induced Mouse AIDS) to investigate early immune response patterns following MuLV infection; comparing disease susceptible and resistant mouse strains for clues to pathways that mediate effective pathogen clearance and immune protection. We use molecular tools to evaluate differential lymphoid tissue gene expression patterns, including host-pathogen DNA microarrays and quantitative real-time PCR assays. These patterns of expression are then confirmed and further explored for their functional significance using several protein assays, including cytokine ELISAs, flow cytometry and fluorescence microscopy. COURSES Biology 220 Cell Biology Spring Biology 319 Immunology Fall Biology 321 Emerging Infectious Disease Seminar Spring SELECTED PUBLICATIONS Tepsuporn, S., J. Horwitt, G. W. Cobb and S.A. Stranford. 2006. MAIDS resistant and susceptible mouse strains differ in their early gene expression profiles after exposure to murine leukemia virus. Manuscript under review. Wong, W., J. S. Billing, S.A. Stranford, K. Hyde, J. Fry, P. J. Morris, and K. J. Wood. 2003. Retroviral transfer of donor MHC Class I or Class II genes into recipient bone marrow cells can induce operational tolerance to alloantigens in vivo. Human Gene Therapy. 14:577-590 Skurich, J., P. Palumbo, A. DeVico, B. Shacklett, F. Valentine, M. Merges, R. Kamin-Lewis, J. Mestecky, R. Denny, G. Lewis, J. Lloyd, R. Praschunus, A. Baker, D. Nixon, S. Stranford, R. Gallo, S. Vermund, and D. Louria. 2002. Correlates of nontransmission in US women at high risk of HIV type 1 infection through sexual exposure. Journal of Infectious Disease. 15;185(4):428-438. Ghanekar, S., S. Stranford, J. Ong, J. Walker, V. Maino and J. Levy. 2001. Decreased HIV-specific CD4 T cell proliferation in long-term HIV-infected individuals on antiretroviral therapy. AIDS. 28;15(14):1885-1887. Stranford, S.A., J. Ong, B. Martinez-Marino, M. Busch, F. Hecht, J. Kahn and J. Levy. 2001. Reduction in CD8+ cell noncytotoxic anti-HIV activity in individuals receiving highly active antiretroviral therapy (HAART) during primary infection. Proceedings of the National Academy of Sciences. 16;98(2):597-602. Stranford, SA, J. Skurnich, D. Louria, D. Osmond, SY. Chang, J. Sninsky, G. Ferrari, K. Weinhold, C. Lindquist, and J. Levy. 1999. Lack of infection in HIV-exposed individuals is associated with a strong CD8+ cell noncytotoxic anti-HIV response. Proceedings of the National Academy of Sciences. 2;96(3):1030-1035. Barker, E., C. Mackewicz, G. Reyes-Teran, A. Sato, S. Stranford, S. Fujimura, C. Christopherson, SY. Chang and J. Levy. 1998. Virological and immunological features of long-term HIV-infected individuals who have remained asymptomatic compared with those who have progressed to AIDS. Blood. 1;92(9):3105-3114. Last Modified: September 6, 2007

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