COURSE TITLE

Biology 328; Regulatory and Integrative Human Physiology

PROFESSOR(S)

Sarah Bacon, sbacon@mtholyoke.edu

LECTURE

MW, 75 mins

LAB

3 Hour Lab Required

TEXTS

Sherwood, L. 2000. Human Physiology: From Cells to Systems. 4th ed. Brooks/Cole.

EXAMS & GRADING

Your grade will be based on exams (60%) and lab work (40%).

Requirement	Point Value
Exams (4 @ 30 each)	120
Lab write-ups (5 @ 10 each)	50
Independent Project - Proposal for ind project (5 points) - Presentation of project (5 points) - Written Report (20 points)	30
Total Points Available	200

LECTURE SCHEDULE

Lecture	Topic	Reading
1	Why study organ systems and whole bodies? Fluid compartments in the body. Homeostasis as an organizing principle in physiology.	Chapter 1
2	The cast of molecular characters and how they get around. Fick's law.
3	Regulating the intracellular environment: the plasma membrane, membrane transport, resting potential, Sherwood chapter 3. Regulating the extracellular environment: the cardiovascular system, a circuit and a pump. Anatomy, electrical activity, mechanical events of the cardiac cycle.	Chapter 9
4	Cardiac output and its control, nourishing the heart muscle.	Chapter 9 and 10
5	Blood, blood vessels and blood pressure continued. Respiration: anatomy, mechanics. Gas exchange, gas transport, control of respiration.	Chapter 13
6	Exam 1
7	The nervous system: neuronal physiology, graded potentials, action potentials. The central nervous system: brain development, landmarks, spinal cord organization.	Chapter 4 Chapter 5
8	Peripheral nervous system. Afferent division, receptor physiology and special senses. Efferent division, somatic and autonomic nervous systems.	Chapter 6 Chapter 7
9	Muscle: structure, molecular basis of contraction. Metabolism and fiber types.	Chapter 8
10	Break
11	Urinary system: anatomy, glomerular filtration.	Chapter 14
12	Exam II
13	Renal physiology: Tubular reabsorption, tubular secretion, urine excretion and plasma clearance.
14	Fluid balance, acid-base balance.	Chapter 15
15	Gastrointestinal system.	Chapter 16
16	Gastrointestinal system. Liver function
17	Central endocrine glands, the pineal, the hypothalamus and pituitary. Peripheral endocrine glands and the stress response.	Chapter 18 Chapter 19
18	Exam III
19	Reproduction	Chapter 20
20	Independent Project Due
21	Reproduction
22	Reading Days
23	Final Exam

LAB SCHEDULE

Week	Topic
1	No Lab
2	No Lab
3	Cardiovascular I: Heart anatomy, heart sounds, heart beat, blood pressure.
4	Cardiovascular II: the pathology laboratory at Bay State Medical Ctr
5	Cardiovascular III: EKG
6	No Lab
7	Respiratory phys I. Lung capacity (VO2 max, MVV, FEV, reserve volume). Exercise physiology.
8	Respiratory phys II, & planning data collection for independent projects.
9	Neural physiology I: The EEG.
10	No Lab
11	Neural physiology II: presentations on central nervous system.
12	No Lab
13	Urinalysis I
14	Urinalysis II: Diabetes case.
15	Components of blood
16	Cirrhosis case. Consulting for independent projects.
17	No Lab
18	Presentations on independent projects. (talk outlines due by 10am the day of lab).

Last Modified: March 11, 2005