Biological Sciences 210
Fall, 2005
GENETICS AND MOLECULAR BIOLOGY
Instructors: Jeff Knight, 105 Clapp, ext. 2487, jknight@mtholyoke.edu
Amy Springer, 120B Carr, ext. 2805, aspringe@mtholyoke.edu
Course Web Site: http://www.mtholyoke.edu/courses/aspringe/biol210.html
Textbook:
R.C. (2002). Modern Genetic Analysis: Integrating Genes
and Genomes. New York, W.H. Freeman and Company, 2nd edition,
ISBN: 0-7167-4382-5
There will also be assigned
readings, and readings available on the World
Wide Web
Please note that there are
prerequisite courses that you must have completed before you enroll in this
class: Biological Sciences 150 (or 145) and Biological Sciences 200. If you have not already taken these courses
(or their approved equivalents), you should not be enrolled in this class. Additionally, if you have not already taken
Chemistry 101 or its approved equivalent, you must be currently enrolled in Chemistry
101 this semester. Please see Mr. Knight
or Ms. Springer if you have any questions about these prerequisites.
The course requirements for
Biology 210 are as follows. There are a
total of 800 points that can be earned:
Course Requirement Total
Points
Midterm Exams (3) 300
Final Exam 200
Quizzes 100
Laboratory
Work (Includes 2 Major Lab Reports)
200
Total points for the
Course = 800
There will be five quizzes
offered throughout the semester on the indicated dates, and each student's
lowest quiz grade will be disregarded.
The three midterm exams will be given on the dates listed below. The final exam will be self-scheduled.
Quiz Dates (NOTE: All Midterm
Exam Dates
quizzes are on Tuesdays.)
Tuesday, September 20
Tuesday, September 27 Wednesday,
October 5
Tuesday, October 18 Wednesday,
November 2
Tuesday,
November 8 Wednesday,
December 7
Tuesday, November 15
TENTATIVE LECTURE SCHEDULE
Introduction to Genetics Chapter
1
The Structure of Genes and
Genomes Chapter
2
Eukaryotic
Chromosome Structure 41-48
RNA
processing 64-66
Protein
Structure 66-68
Gene Function and Mutations Chapters
3 and 10
The molecular basis of mutation 74-81, 315-331
Transposable genetic elements 249-250, 289-290, 302, 331-337
Molecular
basis of dominance and recessiveness 81-84
Intro. to Recombinant DNA Chapter
8
Making recombinant DNA 217-220
Cloning 222-227
Polymerase Chain Reaction (PCR) 220-222
Gel Electrophoresis and
Southern Blotting 230-233
Mendel and the Garden Pea 125-126
Monohybrid Crosses (Complete
Dominance, Incomplete 117-125,
459-463
Dominance, Lethals)
Dihybrid Crosses 150-156
Sex Linkage and Inheritance
Related to Sex 126-128
Human Genetics and Pedigree
Analysis 128-137
Probability I (Binomial
Equation)
Probability II (the
Chi-Square Test) 167-169
Gene Interaction – Epistasis 463-470
Biochemical Genetics 75-81
Complementation 456-459
Multiple Alleles
Penetrance and Expressivity 471-472
Linkage and Recombination 156-167
Genomics, and The Human
Genome Project Chapters
8 and 9
Making and Using DNA Libraries 227-233, and Lab
Manual Project 1
Mapping Human Genes 266-280
Positional Cloning 232-234
DNA Sequencing 236-239
The Human Genome Project 269-271,
280-308
Genetic Testing 239-242
Genetic Engineering and Gene
Therapy 243-255
Review of Drosophila Embryonic Development 509-542
Regulation of gene transcription Chapter 13
Identification of Genes
Controlling Fly Embryonic Development 527
Homeotic genes, Homeoboxes,
Homeodomains, and The Hox genes 537-540, 544-545
251-252
Changes in chromosome number
and structure Chapter
11
Quantitative inheritance Chapter
18