Week of |
Monday (lecture) |
Tuesday (computers) |
Wednesday (lecture) |
Friday (lit presentations) |
Corresponding Chapters |
Sept. 1 |
|
|
|
Introduction, Proteins as linear
Polymers
|
B&T
Ch 1
|
Sept. 8 |
Functional Groups and
Reactivity |
1: Intro to PDB, RasMol |
Secondary Structure Elements |
Helix Packing and Domains |
B&T Ch 2,3
|
Sept. 15 |
Mandatory library workshop |
2: Intro to PDB, RasMol |
Structure Determination |
Beta Sheets; Mass spectrometry |
Creighton p. 20-47
|
Sept. 22 |
Structure Determination |
3: DeepView: Structures |
Structure Determination: X-ray |
What
makes a good structure? |
B&T Ch 18
Kendrew's Nobel Address |
Sept. 29 |
Structure Determination: NMR
|
Mountain
Day!
No problem Set #4
|
Protein Folding |
The Protein Folding Problem |
B&T
Ch 6
(p. 89-99)
|
Oct. 6 |
Structure Prediction and Proteomics |
5:Homology
searching, BLAST, SCOP |
Evolution, Protein Families, SCOP |
Proteomics: Fact and Fiction |
B&T Ch 17, & skim Ch 4-5
Creighton Ch. 3 |
Oct. 15 |
Fall Break |
Fall Break |
Protein Design and Artificial Proteins |
Artificially Designed Proteins |
B&T
Ch 17
|
Oct. 20 |
Exam #1 |
6: Proteins, the Web, and beyond |
Catalysis-General, Kinetics |
Catalysis
and Active Site Probes |
NEW! Berg, Tymoczko, and Stryer, ch 8
(book on reserve) |
Oct. 27 |
Catalysis-Serine Proteases |
7: Active Sites and Inhibitors |
Catalysis-Metalloenzymes |
|
B&T Ch 11
|
Nov. 3 |
Metalloproteins |
8:
Metalloproteins |
Metalloproteins-Spectroscopy |
CuZnSOD
siderophores |
|
Nov. 10 |
DNA Metalloenzymes |
9: DNA binding and recognition |
Protein Recognition of DNA |
|
B&T Ch 7-10
|
Nov.17 |
Membrane Proteins |
10:
Membrane Proteins |
Analysis of Membrane Proteins |
Ion Channels and Transporters |
|
Nov. 24 |
Electron Transfer Proteins, Photosynthetic
Rxn Cntr |
11:
Electron Transfer Proteins |
Thanksgiving Break |
Thanksgiving Break |
B&T Ch.
12
|
Dec. 1 |
Antibodies and Immune Proteins |
12: Antibodies and Viral Symmetry |
Exam
#2 |
Viruses |
B&T Ch 15, 16
|
Dec. 8 |
Presentations |
(free time to work on final exam ?s) |
Presentations |
no class (reading period) |
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|
Dec. 15 |
no class (final exam week) |
no class (final exam week) |
Take-home Final Exam due 5pm |
|
|