Renovated in 2002, the Art Building houses studios for painting, sculpture, and printmaking, the Mount Holyoke College Art Museum, and the art history department office. The sculpture facilities are the most extensive in the Five College area, offering study in a variety of media including wood, clay, plaster, and metal. The College is also home to one of only two bronze casting foundries on the East Coast. (The other is at the Rhode Island School of Design.)

Gamble Auditorium, named for Sidney Gamble, trustee and benefactor of the College, is also located in the Art Building. Lectures and other events take place in Gamble regularly.

A short distance away from the Art Building, in the Central Services Building, is a spacious, well-lit drawing studio. A student-run gallery devoted to student artwork is located in Blanchard Campus Center.