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October 25, 2002

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Wishes Granted The National Science Foundation (NSF) has awarded $226,560 to Steven Dunn, associate professor of geology; Amy Frary, assistant professor of biological sciences; Craig Woodard, associate professor of biological sciences; Darby Dyar, associate professor of astronomy and geology; and Wei Chen, Mary E. Woolley Assistant Professor of Chemistry, under the Major Research Instrumentation Program to acquire for the College a new environmental scanning electron microscope with a low-vacuum sample chamber and energy-dispersive spectrometer. Scanning electron microscopes allow high resolution studies of texture and composition of both organic and inorganic materials. Older instruments require complicated specimen preparation (that sometimes destroys what scientists are trying to observe). The new instrument will allow faculty and students to examine both hydrated and uncoated samples, which cannot be done with the present microscope. A key factor in the receipt of the grant was the quality of the research that the submitting faculty members are currently doing and the ways in which they will be able to use the new instrument. Specific studies planned include taxonomic investigations of freshwater invertebrates, studies of the wetting properties of latex-coated industrial materials, studies of graphite-calcite carbon isotopic exchange during metamorphism as a proxy of the temperature of formation of metamorphic assemblages, compositional mapping of Fe-rich mantle phases to better understand deep earth chemical dynamics and redox conditions, and taxonomic investigations of agriculturally engineered crops. Mark McMenamin, professor of geology, and Leszek Bledzki, senior research associate of biological sciences, also contributed to the proposal.

The NSF also awarded $82,095 to Sue Ellen Gruber, Christianna Smith Professor of Biological Sciences; Craig Woodard; Sarah Bacon, Clare Boothe Luce Assistant Professor of Biological Sciences; Sharon Stranford, Clare Boothe Luce Assistant Professor of Biological Sciences; and Susan Barry, associate professor of biological sciences, under the Major Research Instrumentation Program. These funds will be used to acquire for the College high resolution light microscopy and image processing instruments (in particular, a research-quality fluorescence microscope coupled to a high resolution cooled CCD camera and computer hardware and software appropriate for image processing). Despite the advent of electron and atomic force microscopes, light microscopy is still the core tool for investigating a number of diverse biological questions. The new instruments will become part of an integrated microscopy facility that will complement the existing electron microscopes with up-to-date sophistication in the several modes of light microscopy. Projects under investigation by the five participating biology faculty members are wide ranging. One examines the immunological interactions between a mother and fetus that influence the success of pregnancy. A second explores the action of antimalarial drugs in microorganisms. A third, unique in North America, aims to document the biodiversity of neglected invertebrate groups. The remaining projects dissect the events giving rise to programmed cell death in plants, sort out the identity of cell surface features that may be responsible for AIDS-related immunodeficiency in mice, and examine the role of steroid hormones in the development of fruitflies. In all instances, the enhanced ability to obtain and process high quality microscope images will open up new avenues of experimentation for faculty and students.

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