Publications at Mount Holyoke
*undergraduate
authors
9. Rumora, A.E.*, Kolodziejczak, K.M.*, Malhowski Wagner, A.M.*, Núñez, M.E. (2008) Thymine Dimer-Induced Structural Changes to the DNA Duplex Examined with Reactive Probes, Biochemistry 47, 13026-13035.
8. Volle, C.B.*, Ferguson, M.A., Aidala, K.E., Spain, E.M., Núñez, M.E. (2008) Spring Constants and Adhesive Properties of Native Bacterial Biofilm Cells Measured by Atomic Force Microscopy. Coll. Surf. B: Biointerfaces 67, 32-40.
7. Volle, C.B.*, Ferguson, M.A., Aidala, K.E., Spain, E.M., Núñez, M.E. (2008) Quantitative Changes in the Elasticity and Adhesive Properties of E. coli ZK1056 Prey Cells During Predation by Bdellovibrio bacteriovorus 109J. Langmuir 24, 8102-8110.
6. Ferguson, M.A., Schmitt, J.*, Sindhurakar, A.R.*, Volle, C.B.*, Núñez, M.E, Spain, E. M. (2008) Rapid Isolation of Host-Independent Bdellovibrio bacteriovorus. J. Microbiol. Meth. 73, 279-281.
5. Vladescu, I.D., McCauley, M.J., Núñez, M.E.,
Rouzina, I., Williams, M.C. (2007) Quantifying Force-Dependent and
Zero-Force DNA Intercalation by Single-Molecule Stretching. Nature
Meth. 4, 517-522 .
4. Núñez, M.E., Spain, E.M. (2006)
Investigating a Bacterial Killer Using Atomic Force Microscopy. Microbiol.
Today 33, 100-103.
3. Mihailovic, A.*, Vladescu, I., McCauley, M., Ly, E.*, Williams,
M.C., Spain, E.M., Núñez, M.E.(2006)
Exploring the Interaction of Ruthenium(II) Polypyridyl Complexes with
DNA Using
Single-Molecule Techniques. Langmuir 22, 4699-4709.
2. Núñez, M.E., Martin, M.O., Chan,
P.H.*, Spain, E.M. (2005) Predation, Death, and Survival in a Biofilm:
Investigating
Bdellovibrio by Atomic Force Microscopy. Coll.
Surf. B: Biointerfaces 42, 263-271.
1. Núñez, M.E., Martin, M.O., Chan,
P. H.*, Duong, L.K.*, Sindhurakar, A.R.*, Spain, E.M. (2005) Atomic
Force
Microscopy of Bacterial Communities. Meth. Enzymol. 397, 256-268.
Other Publications
12. Núñez, M.E., Martin, M.O., Duong,
L.K.*, Ly, E.*, Spain, E.M. (2003) Investigations into the Life Cycle
of the
Bacterial Predator Bdellovibrio bacteriovorus 109J at an
Interface by Atomic
Force Microscopy. Biophys. J. 84, 3379-3388.
11. Núñez,
M.E., Noyes, K.T.*, Barton, J. K. (2002) Oxidative
Charge Transport in Nucleosome Core Particles. Chem. & Biol.
9, 403-415
10. Núñez, M. E., Holmquist, G.P.,
Barton, J. K. (2001) Evidence for Charge Transport in the Nucleus. Biochemistry
40, 12465-12471.
9. Núñez, M.E., Noyes, K.T.*, Gianolio,
D., McLaughlin, L.W., Barton, J.K. (2000) Long-Range Guanine
Oxidation in DNA
Restriction Fragments by a Triplex-Directed Naphthalene
Diimide Intercalator.
Biochemistry 39, 6190-6199.
8. Núñez, M. E., Barton,
J.K. (2000) Probing DNA Charge Transport with Metallointercalators.
Curr. Op. Chem. Biol.
4, 199-206.
7. Núñez, M.E., Rajski, S.R., Barton,
J.K. (2000). Damage to DNA by Long-Range Charge Transport.
Meth. Enzymol. 319, 165-188.
6. Vicic, D.A., Odom, D.T., Núñez,
M.E., Gianolio, D., Mc. Laughlin, L.W., Barton, J.K. (2000)
Oxidative Repair
of a Thymine
Dimer in DNA from a Distance by a Covalently Linked
Organic Intercalator.
J. Am. Chem. Soc 122, 8603-8611.
5. Núñez, M.E., Hall,
D.B., Barton, J.K. (1999) Long-Range Oxidative
Damage to DNA: Effects of Distance and Sequence. Chem. & Biol.
6, 85-97.
4. Dandliker, P. J., Núñez, M. E.,
Barton, J. K. (1998) Oxidative Charge Transfer to Repair
Thymine Dimers and
Damage Guanine
Bases in DNA Assemblies Containing Tethered Metallointercalators.
Biochemistry 37, 6491-6502.
3. Núñez, M.*, Ferguson,
J.E.*, Machecek, D., Jacob, G., Oda, R. P.,
Lawson, G., Landers, J. (1995) Detection of Hypoglycemic
Drugs in Human Urine Using Micellar Electrokinetic
Chromatography.
Anal.
Chem. 67, 3668-3675.
2. Ji, A., Núñez, M.*, Machecek,
D., Ferguson, J.*, Iossi, M.*, Kao, P., Landers,
J. (1995) Separation of Urinary
Estrogens
by
Micellar Electrokinetic Chromatography. J. Chromatogr. 669,
15-26.
1. Strausbauch,
M. A., Xu, S.J., Ferguson, J.E.*, Nuñez,
M. E.*, Machecek, D., Lawson,
G. M., Wettstein, P.J., Landers, J. (1995)
Concentration
and Separation of Hypoglycemic Drugs Using
Solid-Phase Extraction-Capillary
Electrophoresis. J. Chromatogr. 717, 279-291.
Grants, Fellowships, and
Awards
PI, National Institutes of Health (NIGMS) AREA program "Effect of Base Lesions on the DNA Duplex" (2008-2011)
Co-PI, Howard Hughes Medical Institute, Undergraduate Science Education Award (2008-2011)
Radcliffe Institute Fellow, Radcliffe Institute for Advanced
Study at Harvard University (2006-2007)
Co-PI, NSF Research at Undergraduate Institutions, "RUI: Interfacial
Chemistry of the Bacterial Predator Bdellovibrio" (2005-2009)
Co-PI, NSF Major Research Instrumentation Grant, "MRI: Acquisition
of Genomics Instrumentation at Mount Holyoke College" (2005-2007)
Co-PI, National Science Foundation Nanotechnology in Undergraduate
Education, "Integration of Nanotechnology into the Core Chemistry
Curriculum
at Mount Holyoke College" (2004-2006)
PI, Camille and Henry Dreyfus Faculty Start-up Grant for Undergraduate
Institutions "Needle in a Haystack: Removing Base Lesions from
DNA" (2003-2008)
Co-PI, National Science Foundation Major Research Instrumentation
Grant, "Acquisition of an Atomic Force
Microscope at Mount Holyoke College" (2003-2005)
Howard Hughes Predoctoral Fellowship in Biochemistry (1996)
Phi Beta Kappa induction (1996)
Barry M. Goldwater Scholar (1994)
Seminars, Presentations, and Posters
"Peer-Led Undergraduate Mentoring System (PLUMS)" (presentation and panel discussion), Union College, Consortium on High Achievement and Success, May 22, 2009.
"Exploring Biochemical and Biophysical Complexity of Native Bacterial Biofilms with Atomic Force Microscopy" (seminar), Department of Chemical and Biochemical Engineering, Washington State University, April 22, 2009.
"Physical Properties of Native Biofilm Cells Explored Using Atomic Force Microscopy" (poster), Biophysical Society National Meeting, February 2009.
"Effect of Base Lesions on Duplex DNA" (seminar), Barnard College, April 4, 2008.
"Effect of Base Lesions on the DNA Duplex" (seminar) California Institute of Technology, January 13, 2008.
"Effect of Base Lesions on the DNA Duplex" (seminar) College of the Holy Cross, September 21, 2007.
"Effect of Base Lesions on Duplex DNA" (poster), American Chemical Society National Meeting, August 2007.
"Effect of Base Lesions on Duplex DNA," (poster), 15th Annual Conversation
on Biomolecular Structure and Dynamics, SUNY Albany, NY, June 2007.
"Needle in a Haystack: Removing Base Lesions from DNA," (seminar)
Radcliffe Institute for Advanced Study, Harvard University, March 2007.
"Life at the Nanoscale: Applications of Atomic Force Microscopy to
Biological Systems" (seminar) Wellesley College, June 22, 2005.
"Interaction of Octahedral Ruthenium Complexes with DNA by Atomic
Force Microscopy" (poster) American Chemical Society National
Meeting,
August 2004.
"Integration of Peer-Led Workshops into the Organic Chemistry Curriculum"
(seminar) American Chemical Society National Meeting, August 2004.
"Life at the Nanoscale: Applications of Atomic Force Microscopy to
Biological Systems" (seminar) Smith College, November 13, 2003.
"Long-Range Damage to DNA" (poster) Gordon
Research Seminar: Eukaryotic DNA Repair, January 2003
"Long-Range Damage to DNA in Nucleosomes" (poster) Gordon
Research Seminar: Nucleic Acids, June 2002
"
Long-Range Oxidation of Guanine Bases in DNA by Metallointercalators" (seminar)
Gordon Graduate Research Seminar: Bioinorganic Chemistry,
January 2001
"Long-Range Charge Transport to Oxidize Guanine Bases in DNA" (seminar)
HHMI Meeting of Predoctoral and Physician Postdoctoral Fellows, September
2000.
"Charge transport through DNA in biological systems" (seminar)
American Chemical Society National Meeting, March 2000.
"Oxidation of Guanine Bases by Photoexcited Rh(III) Intercalators
in Cultured Human Cells" (poster) Gordon Graduate Research
Seminar: Bioinorganic Chemistry, January 2000.
"Long-Range Oxidation of Guanine Bases in DNA by Metallointercalators"
(poster) Gordon Graduate Resarch Seminar: Bioinorganic Chemistry,
January 1999
"Long-Range Oxidation of Guanine Doublets by Tethered Rhodium
and Ruthenium Intercalators" (poster) Gordon Graduate Research
Seminar: Bioinorganic Chemistry, January 1998.
Presentations by Undergraduate Students and Collaborators at National Meetings
Catherine Volle: "Characterization of Lipopolysaccharide Monolayers from Bdellovibrio Predator and E. coli Prey," American Society for Microbiology National Meeting, June 2008.
Catherine Volle: "Characterization of Lipopolysaccharide Monolayers from Bdellovibrio Predator and E. coli Prey by Langmuir-Blodgettry and Atomic Force Microscopy," Biophysical Society National Meeting, February 2008.
Catherine Volle: “How Bdellovibrio Recognizes
its Prey: Characterization of Prey and Predator Cell Surface Lipopolysaccharides.” Megan Ferguson: “Structure
and Function of a Pigment Produced by Host-Independent Bdellovibrio
bacteriovorus," American Chemical Society National Meeting, August 2007.
Megan Ferguson: “Probing
Living Escherichia coli Biofilms in Fluid using Quantitative
Atomic Force Microscopy Measurements.” Catherine Volle: “How Bdellovibrio Recognizes
its Prey: Characterization of Prey and Predator Cell Surface Lipopolysaccharides.” Megan Ferguson: “Structure
and Function of a Pigment Produced by Host-Independent Bdellovibrio
bacteriovorus," American Society for Microbiology National
Meeting, May 2007.
Amy Rumora: "Thymine
Dimer-Induced Structural Changes to the DNA Base Pair Stack." Jacqueline Wade: "Measuring
the Rate of Base Lesion Excision from Supercoiled DNA Substrates by
Formamido-pyrimidine Glycosylase." Stephanie Azan: "Characterization of Lipopolysaccharide
Monolayers from Bdellovibrio Predator
and E.coli Prey by Langmuir-Blodgettry and Atomic Force Microscopy."
Catherine Volle: "Characterization of Lipopolysaccharides from Bdellovibrio Predator
and E. coli Prey by Chromatographic, Electrophoretic, and
Spectroscopic Techniques," Biophysical Society
National Meeting,
March 2007.
Dana Vladescu: "Mapping the phase diagram of DNA force-induced melting in the presence of DNA intercalators," Biophysical Society National Meeting, February 2006.
Elaine Ly: "Examination of Groove-Binding and Intercalation into DNA by Atomic Force Microscopy," National Conference on Undergraduate Research, Spring 2005
Elaine Ly: "Examination of Groove-Binding
and Intercalation into DNA by Atomic Force Microscopy" "Visualizing
Bacterial Predation by Atomic Force Microscopy," Biophysical
Society National Meeting, February 2004.
Professional Society Memberships
American Chemical Society
Biophysical Society
American Society for Microbiology
Sigma Xi
College Service
Academic Priorities Committee (2008-2010)
Founder and Coordinator, PLUMS Program, Mount Holyoke College
(2004-Present) Created and organized a peer-led workshop and
mentoring program for General and Organic Chemistry. Presented our
pedagogical developments at the Chemical Education section of the August
2004 ACS National Meeting and the May 2009 meeting of CHAS.
Biochemistry Program Committee member (2003-present)
HHMI Summer Research Program selection committee (Spring 2005 and 2006)
HHMI Science Curriculum Working Group (2004-2006)
Prehealth Professions Committee member (2007-present)
Frances Harriet Williams Award selection committee member (2004-2006)
Professional Service and Outreach
Panelist, HHMI Gilliam Graduate Fellows Workshop, Chevy Chase MD (May 2009)
Panelist, National Symposium on the Advancement of Women in Science, Harvard University (Spring 2007)
Invited speaker, Harvard Women in Chemistry (Fall 2006)
Invited speaker, Harvard Women in Physics (Fall 2006)
Panelist, Lyon's Network "Conference on Leadership and Careers," Mount Holyoke College (Spring 2006)
Panelist, ALANA Science student symposium, Smith College (Spring 2005)
Reviewer Grant reveiwer for the National Science Foundation. Manuscript reveiwer for the Journal of the American Chemical Society, Langmuir, Ultramicroscopy, Micron, Microscopy and Analysis, and Microbiology.
Chair, Gordon Research Conference: Graduate
Seminar in Bioinorganic Chemistry (2000). Also vice-chair (1999) and representative
to the GRC (2000).
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