Assistant Professor of Biological Sciences
A.B. Molecular Biology, Princeton University, 1997
Ph.D. Biological Chemistry and Molecular Pharmacology, Harvard University, 2003
Department of Molecular and Cellular Biology, Harvard University, 2004-2010
Bacterial cell-cell communication and gene regulation
Upon nutrient starvation, the bacterium Bacillus subtilis transforms itself into a metabolically dormant spore. This primitive developmental process involves two sister cells, only one of which becomes a spore.
The Camp Lab eavesdrops on these two developing cells to discover the elegant and unexpected ways that they communicate and control gene expression.
Project 1. Dissect the structure and function of a “feeding tube” that connects the two sporulating cells.
Project 2. Examine how “switches” in gene expression occur within an individual sporulating cell.
- Biology 220 Cell Biology (spring)
- Biology 336 Bacterial Cell Biology (fall)
Camp AH, Wang AF, and Losick R. (2011) A small protein required for the switch from σF to σG during sporulation in Bacillus subtilis. J Bacteriol 193: 116-124.
Schmalish M, Maiques E, Nikolov L, Camp AH, Chevreux B, Muffler A, Rodriguez S, Perkins J, and Losick R. (2010) Small genes under sporulation control in the Bacillus subtilis genome. J Bacteriol 192: 5402-5412.
Camp AH and Losick R. (2009) A feeding tube model for activation of a cell-specific transcription factor during sporulation in Bacillus subtilis. Genes Dev 23: 1014-1024.
Camp AH and Losick R. (2008) A novel pathway of intercellular signaling in Bacillus subtilis involves a protein with similarity to a component of type III secretion channels. Mol Microbiol 69: 402-417.
Ferguson CC, Camp AH, and Losick R. (2007) gerT, a newly discovered germination gene under the control of the sporulation transcription factor sK in Bacillus subtilis. J Bacteriol 189: 7681-7689.