2015 Chemistry Department Annual Lucy Pickett Lecture
Joan-Emma Shea from the Department of Chemistry and Biochemistry at the University of California, Santa Barbara, CA will be speaking on the effect of surfaces in modulating protein folding and aggregation mechanisms.
Philip S. Lukeman, Associate Professor of Chemistry, St. John's University
DNA-based switches are currently operated by manual, solution-phase addition of 'set-strands'. I will describe another operation method - sterically inaccessible 'set=strands', released from a surface into solution by spatially controlled photocleavage, that operates both stochiometric and nucleated set-strand controlled systems. This technique will enable microarrays of set-strands to operate many DNA-based switches in computational and diagnostic devices.
I will also describe preliminary work using DNA origami 'claw' decorated with viral capsid complementary recognition elements that undergoes a large conformational change if and only if whole virus is present. We expect these claws to act as prototypes of the key components for a self-contained, low background, portable, electrochemical biosensor; a biosensor that is capable of sensing pathogenic viruses in neat, unprocessed biological fluids.
Biochemistry and Chemistry Majors Annual Luncheon
Please join us for food, conversation and to celebrate the end of the semester.