Mount Holyoke College

In vivo cytoskeletal dynamics of living fish embryos
Movie #3:Deep cell locomotion: Actin Retrograde Flow


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Cell migration depends on the rapid lengthening and shortening of actin filaments, as new subunits are added near the front of the cell, and filaments are depolymerized farther back. This leads to a net retrograde (towards the rear end of the cell) flow of actin. In this video you can see this cyclic wave of actin as an individual cell is crawling.