Andrea Foulkes

Professor of Mathematics and Statistics; on leave 2019-20
Biostatistics, statistical genetics, big data applications

Andrea Foulkes is Professor and Chair, Department of Mathematics and Statistics and co-Director of the Program in Data Science. Her scholarship is in clinical biostatistics and statistical genetics.  Her work includes developing methods for high-dimensional molecular and cellular data and measures of disease progression with applications in inflammatory disease, cardio-metabolic disease and HIV/AIDS. Her methodological developments draw on theories in mixed effects modeling, Markov modeling, supervised and unsupervised learning and ensemble methods. In addition to her methods research in biostatistics, she authored the graduate level textbook "Applied Statistical Genetics with R" in 2009 for Springer's UseR! Series, and has since developed extensive open-source and extensible education resources in statistical genetics.  

News Links

"Big Data, Infinite Possibilities" Office of Communications and Marketing, July 12, 2018

"Mount Holyoke Professor Receives Grant from National Institute of General Medical Science" Mount Holyoke News, October 19, 2017

Recent Publications

A score test for genetic class-level association with nonlinear biomarker trajectories. Qian J, Nunez S, Kim S, Reilly MP, Foulkes AS. Stat Med. 2017 Aug 30;36(19):3075-3091. doi: 10.1002/sim.7314. Epub 2017 May 23.

Bayesian variable selection for post-analytic interrogation of susceptibility loci. Chen S, Nunez S, Reilly MP, Foulkes AS. Biometrics. 2017 Jun;73(2):603-614. doi: 10.1111/biom.12620. Epub 2016 Nov 17.

Genome-wide interrogation reveals hundreds of long intergenic noncoding RNAs that associate with cardiometabolic traits. Ballantyne RL, Zhang X, Nuñez S, Xue C, Zhao W, Reed E, Salaheen D, Foulkes AS, Li M, Reilly MP. Hum Mol Genet. 2016 Jul 15;25(14):3125-3141. Epub 2016 Jun 10.

HIV-1-negative female sex workers sustain high cervical IFNɛ, low immune activation, and low expression of HIV-1-required host genes. Abdulhaqq SA, Zorrilla C, Kang G, Yin X, Tamayo V, Seaton KE, Joseph J, Garced S, Tomaras GD, Linn KA, Foulkes AS, Azzoni L, VerMilyea M, Coutifaris C, Kossenkov AV, Showe L, Kraiselburd EN, Li Q, Montaner LJ. Mucosal Immunol. 2016 Jul;9(4):1027-38. doi: 10.1038/mi.2015.116. Epub 2015 Nov 11.

A guide to genome-wide association analysis and post-analytic interrogation. Reed E, Nunez S, Kulp D, Qian J, Reilly MP, Foulkes AS. Stat Med. 2015 Dec 10;34(28):3769-92. doi: 10.1002/sim.6605. Epub 2015 Sep 6.